Dihydroxyacetone Induced Autophagy in African Trypanosomes
نویسندگان
چکیده
منابع مشابه
Dihydroxyacetone induced autophagy in African trypanosomes.
Dihydroxyacetone (DHA) was examined to explore its trypanocidal activity. The compound is easily taken up by trypanosomes via its aquaglyceroporins but is not converted to a glycolytic intermediate due to the lack of a respective kinase. Investigating the DHA-induced cell death it became evident that parasites die by autophagy rather than by necrosis or apoptosis. Since autophagy is not well st...
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Parasites have developed clt~\'et tricks to evade the deadly immune detense o( d~eu mammalian hosts. Rep.ularly chanting surface coats, that is, anti~enic variation, is one ot the most appealing ~f these trick>. \Vhat ((ruld Be simpler and more effect~\c than t~ fool the immune system ol the host b b regularly changing sudacc al~t igens tllOtt' rapidly thm~ new antibodies can bc made? But m pra...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2007
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.4907